ALLSCHWIL/BASEL, SWITZERLAND - 27 August 2013 - Actelion Ltd (SIX: ATLN) announced today that it has appointed André C. Muller (49) as the company's Chief Financial Officer and member of Actelion's Executive Committee (AEC). He succeeds Andrew J. Oakley (51), who will focus on opportunities outside Actelion. Mr. Muller will take office on01 September 2013.

Jean-Paul Clozel, M.D. and Chief Executive Officer of Actelion, commented: "I am pleased to welcome André Muller as Chief Financial Officer at Actelion. He brings vast experience as a pharmaceutical finance executive and I am confident that André will make a significant contribution to Actelion's continued success."

André C. Muller is a French citizen joining Actelion from Pierre Fabre SA, an international pharmaceutical and cosmetic group, where he held various positions from 1994 until 2011, most recently as Chief Financial Officer. He holds an MBA from the Business School EM, Lyon

Thanking Andrew Oakley for his contribution, Jean-Paul Clozel said: "Over the last decade Andrew has led Actelion's finance office, supporting our significant expansion. We wish him every success for his future."

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NOTES TO THE EDITOR

ABOUT ACTELION LTD Actelion Ltd is a biopharmaceutical company with its corporate headquarters in Allschwil/Basel, Switzerland. Actelion's first drug Tracleer® (bosentan), an orally available dual endothelin receptor antagonist, has been approved as a therapy for pulmonary arterial hypertension. Actelion markets Tracleer through its own subsidiaries in key markets worldwide, including the United States (based in South San Francisco), the European Union, Japan, Canada, Australia and Switzerland. Actelion, founded in late 1997, is a leading player in innovative science related to the endothelium - the single layer of cells separating every blood vessel from the blood stream. Actelion's over 2,300 employees focus on the discovery, development and marketing of innovative drugs for significant unmet medical needs. Actelion shares are traded on the SIX Swiss Exchange (ticker symbol: ATLN) as part of the Swiss blue-chip index SMI (Swiss Market Index SMI®).

For further information please contact: Roland Haefeli Senior Vice President, Head of Investor Relations & Public Affairs Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil +41 61 565 62 62 +1 650 624 69 36 www.actelion.com

The above information contains certain "forward-looking statements", relating to the company's business, which can be identified by the use of forward-looking terminology such as "estimates",  "believes", "expects", "may", "are expected to", "will", "will continue", "should", "would be", "seeks",  "pending" or "anticipates" or similar expressions, or by discussions of strategy, plans or intentions.  Such statements include descriptions of the company's investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company's existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.